861853-59-0Relevant academic research and scientific papers
Synthesis and monoamine transporter affinity of 3α-arylmethoxy-3β-arylnortropanes
Kaur, Harneet,Izenwasser, Sari,Verma, Abha,Wade, Dean,Housman, Amy,Stevens, Edwin D.,Mobley, David L.,Trudell, Mark L.
supporting information; experimental part, p. 6865 - 6868 (2010/06/16)
A series of 3-arylnortrop-2-enes and 3α-arylmethoxy-3β-arylnortropanes were synthesized and evaluated for binding affinity at monoamine transporters. The 3-(3,4-dichlorophenyl)nortrop-2-ene (6e) exhibited high affinity for the SERT (Ki = 0.3 nM
2,6-Disubstituted piperiddines as modulators
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Page/Page column 21, (2010/11/28)
The present invention is further directed to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R16, R17, R18, R19, R20, R21 and R22 are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
