86187-37-3

Upstream product

• 82720-45-4 benzyl N-(4-amino-2-methoxy-phenyl)carbamate 
• 86187-36-2 dimethyl N-<4-<(benzyloxy)carboxamido>-3-methoxyphenyl>phosphoramidate 
• 82720-44-3 N-benzyloxycarbonyl-2-methoxy-4-nitroaniline 

Downstream Products

• 86187-29-3 [3-Methoxy-4-(4-methylcarbamoyl-acridin-9-ylamino)-phenyl]-phosphoramidic acid dimethyl ester; hydrochloride 
• 82720-44-3 N-benzyloxycarbonyl-2-methoxy-4-nitroaniline 
• 86187-27-1 [3-Methoxy-4-(4-methoxy-acridin-9-ylamino)-phenyl]-phosphoramidic acid dimethyl ester 
• 90172-05-7 [3-Methoxy-4-(2-methyl-acridin-9-ylamino)-phenyl]-phosphoramidic acid dimethyl ester; hydrochloride 
• 82720-41-0 [4-(Acridin-9-ylamino)-3-methoxy-phenyl]-phosphoramidic acid dimethyl ester 
• 86187-24-8 [4-(3-Bromo-acridin-9-ylamino)-3-methoxy-phenyl]-phosphoramidic acid dimethyl ester; hydrochloride 
• 86187-31-7 [3-Methoxy-4-(4-methyl-acridin-9-ylamino)-phenyl]-phosphoramidic acid dimethyl ester 

Relevant academic research and scientific papers

Certain acridinyl-phosphoramidate compounds

The novel class of compounds of the present invention represented by the general formula (I): STR1 in which R1 represents H or OCH3, R2 represents H, OCH3, CH3, halogen, NO2, NH2, NHCOCH3 or NHCOOCH3, and R3 and R4 individually represent H, CH3, OCH3 or CONHCH3, and the acid addition salts thereof, have unexpectedly high potency and activity in in vivo antitumour tests. The compounds are also bacteriostatic, and show toxicity towards mouse, hamster and human tumour cell lines in culture.

Potential antitumor agents. 42. Structure-activity relationships for acridine-substituted dimethyl phosphoramidate derivatives of 9-anilinoacridine

Replacement of the 1'-methanesulfonamide group of the 9-anilinoacridine class of antitumor agents with the 1'-(dimethyl phosphoramidate) group provides compounds that are generally more lipophilic and bind more tightly to DNA. On the average, the dimethyl