861872-87-9

Upstream product

• 861872-86-8 (1R,2R,5R,6R,7R,7aR)-1,2-dibenzyloxy-3-tert-butyldiphenylsilyloxymethyl-6,7-dihydroxypyrrolizidine 
• 861872-85-7 (1S,2R,5R,6R,7R,7aR)-6,7-dibenzyloxy-5-tert-butyldiphenylsilyloxymethyl-1,2-dihydroxypyrrolizidin-3-one 
• 861872-76-6 (2R,3R,4R,5R)-3,4-dibenzyloxy-N-benzyloxycarbonyl-2'-O-tert-butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine 
• 861872-77-7 methyl (E)-3-[(2'R,3'R,4'R,5'R)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propenoate 
• 861872-79-9 methyl (2R,3S)-2,3-dihydroxy-3-[(2'R,3'R,4'R,5'R)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propanoate 
• 487040-55-1 (2R,3R,4R,5R)-3,4-dibenzyloxy-2'-O-tert-butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine 
• 1204748-28-6 (1aR,4R,5R,6R,6aS,6bS)-5,6-bis(benzyloxy)-4-((tertbutyldimethylsilyloxy)methyl)hexahydro-1aH-oxireno[2,3-a]pyrrolizine 

Downstream Products

• 159440-57-0 casuarine 

Relevant academic research and scientific papers

Total synthesis of uniflorine A, casuarine, australine, 3-epi-australine, and 3,7-di-epi-australine from a common precursor

(Chemical Equation Presented) Aflexible method for the diastereoselective total synthesis of the pyrrolizidine alkaloids uniflorine A, casuarine, australine, and 3-epi-australine and the unnatural epimer 3,7-di-epi-australine from a common chiral 2,5-dihydropyrrole precursor is described. 2009 American Chemical Society.

Polyhydroxylated pyrrolizidines. Part 6: A new and concise stereoselective synthesis of (+)-casuarine and its 6,7-diepi isomer, from DMDP

A new synthesis for (+)-casuarine (1) and its 6,7-diepi isomer (15) in a stereocontrolled manner, is reported herein. An appropriately protected polyhydroxylated pyrrolidine, such as (2R,3R,4R,5R)-3,4-dibenzyloxy-2′-O- tert-butyldiphenylsilyl-2,5-bis(hydr