861902-75-2

Upstream product

• 861902-74-1 (1S,2'R,3'R,4'R,5'R)-1-[3',4'-bis(tert-butyldimethylsilanyloxy)-5'-trityloxymethyltetrahydrofuran-2'-yl]ethanol 
• 107-30-2 chloromethyl methyl ether 
• 220772-72-5 (2S,3R,4R,5R)-3,4-di-tert-butyldimethylsilyloxy-2-formyl-5-(1-trityloxymethyl)tetrahydrofuran 

Downstream Products

• 861902-78-5 (1'S,2S,5S)-2-(1'-methoxymethoxyethyl)-5-trityloxymethyl-2,5-dihydrofuran 
• 861902-77-4 (1'S,2R,3R,4R,5R)-3,4-(dimethanesulfonyloxy)-2-(1'-methoxymethoxyethyl)-5-trityloxymethyltetrahydrofuran 
• 861902-76-3 (1'S,2R,3R,4R,5R)-2-(1'-methoxymethoxyethyl)-5-trityloxymethyltetrahydrofuran-3,4-diol 

Relevant academic research and scientific papers

Stereoselective synthesis of (2R,3S,4S)-3-hydroxy-4-methyl-2-tetradecyl-4- butanolide starting from 2,5-anhydro-D-mannitol

A novel approach to natural β-hydroxy-γ-lactone 2 from 2,5-anhydro-d-mannitol (1) is described. The key reactions in this synthesis include stereoselective methylation of aldehyde 3 with lithium dimethylcuprate, an intramolecular radical cyclization of seleno carbonate 11 and an intermolecular cross-metathesis of 3-allyl-4-hydroxy-γ-lactone 16 with 1-tridecene.