861968-00-5Relevant academic research and scientific papers
New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity
Zhang, Yali,Liu, Zhiguo,Wu, Jianzhang,Bai, Bin,Chen, Hongjin,Xiao, Zhongxiang,Chen, Lingfeng,Zhao, Yunjie,Lum, Hazel,Wang, Yi,Zhang, Hong,Liang, Guang
, p. 291 - 305 (2018)
An overactive Toll-like receptor (TLR) signaling complex is a significant pathogenic factor of acute and chronic inflammatory diseases. The natural product curcumin is reported to inhibit the TLR4 co-receptor, MD2 (myeloid differentiation protein 2), but
Synthesis of Curcumin Analogues as Potential Antioxidant, Cancer Chemopreventive Agents
Youssef, Khairia M.,El-Sherbeny, Magda A.,El-Shafie, Faiza S.,Farag, Hassan A.,Al-Deeb, Omar A.,Awadalla, Sit Albanat A.
, p. 42 - 54 (2007/10/03)
New series of 3,5-bis(substituted benzylidene)-4-piperidones, 2,7-bis(substituted benzylidene)cycloheptanones, 1,5-bis(substituted phenyl)-1,4-pentadien-3-ones, 1,7-bis(substituted phenyl)-1,6-heptadien-3,5-diones, 1,1-bis(substituted cinnamoyl)-cyclopentanes, and 1,1-bis(substituted cinnamoyl)cyclohexanes have been synthesized and tested for their antioxidant activity. Among the tested compounds, compounds II 4, II9 II10, II11, V1, and V4 exhibited higher free radical scavenger activity with % inhibition values of 90.71, 91.24, 96.91, 94.26, 99.23, and 99.85%, respectively. Moreover, compound V1 is the safest member toward peripheral multinuclear neutrophils (PMNs) with a % viability value of 91%. Detailed synthesis, spectroscopic, and biological data are reported.
