862081-02-5

Basic information

• Product Name: 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(6-chloro-purin-9-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester
• Synonyms: 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(6-chloro-purin-9-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester
• CAS NO: 862081-02-5
• Molecular Weight: 749.476
• Mol File: 862081-02-5.mol

Chemical Properties

• CAS DataBase Reference: 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(6-chloro-purin-9-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(6-chloro-purin-9-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester(862081-02-5)
• EPA Substance Registry System: 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(6-chloro-purin-9-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester(862081-02-5)

Safety Data

• Hazardous Substances Data: 862081-02-5(Hazardous Substances Data)

Upstream product

• 862080-84-0 2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ⁴-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester 
• 32865-86-4 6-chloro-9-trimethylsilylpurine 

Relevant articles and documents

Stereoselective synthesis of β-anomeric 4′-thiaspirocyclic ribonucleosides carrying the full complement of RNA-level hydroxyl substitution

Stereoselective syntheses of a group of 4′-thiaspirocyclic ribonucleosides featuring both pyrimidine and purine classes and both possible configurations at C-5′ are described. Use is made of the Pummerer reaction of substrates carrying an α-oriented 2,4-dimethoxybenzoyloxy substituent at C-2 in order to gain reliable stereocontrol via neighboring group participation. Irrespective of the S or R configuration of the pivotal sulfoxide intermediates, the nucleobase is captured from the β-face. The competing process is formation of unsaturated sulfoxides, presumably via competing E2-type elimination. Although differences in reactivity between the two stereoisomeric series were noted, the common route has successfully given rise for the first time to desirable β-anomeric sulfur-containing spiroribonucleosides with minimum formation of the a-anomers.