862081-15-0

Basic information

• Product Name: 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11R)-3-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester
• Synonyms: 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11R)-3-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester
• CAS NO: 862081-15-0
• Molecular Weight: 748.058
• Mol File: 862081-15-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11R)-3-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11R)-3-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester(862081-15-0)
• EPA Substance Registry System: 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11R)-3-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester(862081-15-0)

Safety Data

• Hazardous Substances Data: 862081-15-0(Hazardous Substances Data)

Upstream product

• 14631-20-0 4-N-Acetylcytosine 
• 862081-09-2 2,4-Dimethoxy-benzoic acid (1R,4R,5S,11R)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester 
• 862081-08-1 2,4-Dimethoxy-benzoic acid (3R,4S,5R,6R)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester 
• 862081-07-0 (3R,4S,5R,6R)-1-Thia-spiro[4.4]nonane-3,4,6-triol 
• 849112-80-7 C₁₁H₁₈O₃S 
• 862081-10-5 2,4-Dimethoxy-benzoic acid (1R,2S,4R,5S,11R)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ⁴-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester 
• 54230-57-8 N⁴-acetyl-O-trimethylsilylcytosine 

Relevant articles and documents

Stereoselective synthesis of β-anomeric 4′-thiaspirocyclic ribonucleosides carrying the full complement of RNA-level hydroxyl substitution

Stereoselective syntheses of a group of 4′-thiaspirocyclic ribonucleosides featuring both pyrimidine and purine classes and both possible configurations at C-5′ are described. Use is made of the Pummerer reaction of substrates carrying an α-oriented 2,4-dimethoxybenzoyloxy substituent at C-2 in order to gain reliable stereocontrol via neighboring group participation. Irrespective of the S or R configuration of the pivotal sulfoxide intermediates, the nucleobase is captured from the β-face. The competing process is formation of unsaturated sulfoxides, presumably via competing E2-type elimination. Although differences in reactivity between the two stereoisomeric series were noted, the common route has successfully given rise for the first time to desirable β-anomeric sulfur-containing spiroribonucleosides with minimum formation of the a-anomers.