862107-67-3

Upstream product

• 17869-81-7 methoxy(prop-2-yn-1-yloxy)methane 
• 862107-71-9 (2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butynyl]pyrrolidine 
• 862107-72-0 (2S)-(tert-butyldimethylsilanyloxymethyl)-1-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-4-methoxymethoxy-2-butenyl]pyrrolidine 
• 862107-66-2 (2S,3R,4E)-2-benzyloxy-1-[(2S)-2-(tert-butyldimethylsilanyloxymethyl)pyrrolidin-1-yl]-6-(tert-butyldiphenylsilanyloxy)-3-methoxymethoxymethyl-4-hexenone 

Downstream Products

• 862107-68-4 (3S,4S,5R)-3-benzyloxy-5-[2-(tert-butyldiphenylsilanyloxy)ethyl]-4-methoxymethoxymethyl-2-dihydrofuranone 

Relevant academic research and scientific papers

Asymmetric synthesis of trans-3,4-dialkyl-γ-butyrolactones via an acyl-claisen and iodolactonization route

(Chemical Equation Presented) A new, efficient, and general asymmetric synthesis of enantiomerically pure trans-3,4-dialkyl-γ-lactones has been developed. The key steps are (1) copper-catalyzed three-component coupling of chiral amine, aldehyde, and alkyne, (2) acyl-Claisen rearrangement, and (3) iodolactonization. The products, chiral γ-lactones, are versatile synthetic intermediates and structural units of natural products and modified nucleosides.