862115-68-2Relevant academic research and scientific papers
Pd(II)-Catalyzed Intramolecular C(sp2)-H Arylation of Tryptamines Using the Nonsteric NH2as a Directing Group
Wang, Sixi,Yu, Bin,Liu, Hong-Min
supporting information, p. 42 - 48 (2021/01/09)
The free amine-directed C-H functionalization reactions are challenging and mainly restricted to bulky amines. In this work, we report the nonsteric NH2-directed Pd(II)-catalyzed intramolecular C(sp2)-H arylation of tryptamines, which enables the efficient, gram-scale, and regioselective synthesis of versatile 2-aryltryptamines (35 examples, up to 98% yield). This approach broadens the substrate scope of the free amine-directed C-H functionalization, not limited to bulky amine substrates. Late-stage elaborations of 2-aryltryptamines achieve the divergent construction of the complex core structures that are prevalent in highly valuable natural products such as aurantioclavine, chimonanthine, and phalarine.
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase
Weinstein, David S.,Liu, Wen,Gu, Zhengxiang,Langevine, Charles,Ngu, Khehyong,Fadnis, Leena,Combs, Donald W.,Sitkoff, Doree,Ahmad, Saleem,Zhuang, Shaobin,Chen, Xing,Wang, Feng-Lai,Loughney, Deborah A.,Atwal, Karnail S.,Zahler, Robert,Macor, John E.,Madsen, Cort S.,Murugesan, Natesan
, p. 1435 - 1440 (2007/10/03)
A series of inhibitors of mammalian 15-lipoxygenase based on tryptamine and homotryptamine scaffolds is described. Compounds with aryl substituents at C-2 of the indole core of tryptamine and homotryptamine sulfonamides (e.g., 37a-p) proved to be potent i
