86212-34-2

Basic information

• Product Name: meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98%
• Synonyms: meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98%;1,2-BIS(4-CHLOROPHENYL)-1,2-ETHANEDIAMINE
• CAS NO: 86212-34-2
• Molecular Formula: C₁₄H₁₄Cl₂N₂
• Molecular Weight: 281.18036
• Mol File: 86212-34-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 137-138 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 418.574°C at 760 mmHg
• Flash Point: 206.946°C
• Appearance: /
• Density: 1.303±0.06 g/cm3(Predicted)
• Vapor Pressure: 0mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.32±0.10(Predicted)
• CAS DataBase Reference: meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98%(CAS DataBase Reference)
• NIST Chemistry Reference: meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98%(86212-34-2)
• EPA Substance Registry System: meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98%(86212-34-2)

Safety Data

• Hazardous Substances Data: 86212-34-2(Hazardous Substances Data)

Usage

Description

meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98% is a high-purity chemical compound consisting of two 4-chlorophenyl groups attached to an ethylenediamine molecule in a meso configuration. Its high purity and specific stereochemistry make it a valuable reagent in various industrial and laboratory applications.

Uses

Used in Pharmaceutical Industry:
meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98% is used as a building block for the synthesis of various pharmaceuticals due to its high purity and specific stereochemistry, enabling the production of high-quality and effective drugs.
Used in Agrochemical Industry:
meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98% is used as a key intermediate in the synthesis of agrochemicals, contributing to the development of effective and safe pesticides and other agricultural products.
Used in Organic Synthesis:
meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98% is used as a versatile reagent in organic synthesis, allowing for the creation of a wide range of organic compounds with minimal impurities and specific stereochemical control.
Used in Fine Chemicals Production:
meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98% is used as a crucial component in the production of fine chemicals, including specialty chemicals and high-value compounds for various applications.

InChI:InChI=1/C14H14Cl2N2/c15-11-5-1-9(2-6-11)13(17)14(18)10-3-7-12(16)8-4-10/h1-8,13-14H,17-18H2/p+2/t13-,14+

Upstream product

• 115294-32-1 4-chloro-benzoic acid-[erythro-4,4'-dichloro-α'-(4-chloro-benzylidenamino)-bibenzyl-α-ylamide] 
• 41097-37-4 (1E, 2E)-1,2-bis (4-chlorobenzylidene) hydrazine 
• 104-88-1 4-chlorobenzaldehyde 
• 115294-32-1 C₂₈H₂₀Cl₄N₂O 
• 3848-36-0 4-chlorobenzaldoxime 

Downstream Products

• 870007-53-7 (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole 
• 1402830-14-1 2-(4-tert-butyl-2-ethoxyphenyl)-cis-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole hydrochloride 
• 1353891-92-5 N-((1S,2R)-2-amino-1,2-bis(4-chlorophenyl)ethyl)-2-isopropoxy-4-methoxybenzamide 
• 1353891-93-6 N-((1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethyl)-3-oxopiperazine-1-carboxamide 
• 548472-68-0 nutlin-3a 
• 1353891-88-9 tert-butyl ((1R,2S)-2-amino-1,2-bis(4-chlorophenyl)ethyl)carbamate 
• 1353891-90-3 tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate 
• 844692-35-9 trans-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole 

Relevant articles and documents

MDM2 DEGRADERS AND USES THEREOF

The present invention relates to compounds and methods useful for the modulation of mouse double minute 2 homolog ("MDM2") protein via ubiquitination and/or degradation by compounds according to the present invention.

Dimer ester micromolecule PROTACs for inducing MDM2 to self-degrade E3 ubiquitin ligase

The invention provides dimer ester micromolecule PROTACs for inducing MDM2 to self-degrade E3 ubiquitin ligase. The structure of the PROTACs is shown in the specification, wherein in a compound (I), L1 is C1-C30 linear or branched alkyl with or without a substituent group, and any carbon atom in L1 is optionally replaced by heteroatom; R1, R2, R3 and R4 are C1-C30 linear or branched alkyl with orwithout a substituent group, C1-C30 aryl with or a without substituent group, C1-C30 linear or branched alkylaryl with or without a substituent group or C1-C30 linear or branched aryl alkyl with or without a substituent group respectively and independently; X1, X2, X3 and X4 are halogen respectively and independently.

Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents

p53-Murine double minute 2 (MDM2) interaction and histone deacetylases (HDACs) are important targets in antitumor drug development. Inspired by the synergistic effects between MDM2 and HDACs, the first MDM2/HDACs dual inhibitors were identified, which sho