862180-18-5Relevant academic research and scientific papers
Synthesis of Podands of the 3,4-dihydroisoquinoline series
Shklyaev,Vshivkova
, p. 376 - 380 (2014/06/09)
Podands containing 3,4-dihydroisoquinoline fragments were synthesized by reactions of 1,1′-{ethane-1,2-diylbis[oxy(3-methoxybenzene-4,1-diyl)]} bis(2-methylpropan-1-ol) and 1-(2-ethoxyethoxy)-2-methoxy-4-(2-methylprop-1-en- 1-yl)benzene with ethyl cyanoacetate and methyl thiocyanate in concentrated sulfuric acid. Likewise, 1-substituted 3,4-dihydroisoquinolines having a crown ether fragment were obtained from 4-acetylbenzo-12-crown-4.
3-PHENYL-N- ((1, 3, 4) THIADIAZOL-2-YL) -ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ESTROGEN-RELATED RECEPTORS FOR THE TREATMENT OF E.G. CANCER, RHEUMATOID ARTHRITIS OR NEUROLOGICAL DISORDERS
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Page/Page column 72; 73, (2010/02/13)
Compounds of formula (I) are provided as well as compositions and methods of using compounds of formula (I) for modulating the activity of the estrogen-related receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder related to the activity of the estrogen-related receptor. Considering the wide range of activity of the nuclear hormone receptor ERRα, the compounds described herein which are capable of modulating ERRα activity, are useful for treating a range of disease states including cancer, diabetes, obesity, hyperlipidermia, arthritis, atherosclerosis, osteoporosis, anxiety, depression, Parkinson’s disease and Alzheimer’s disease. Formula (I). The substituents are defined in the claims.
Total synthesis of vibsanol, a benzofuran-type lignan
Sakai, Atsushi,Aoyama, Toyohiko,Shioiri, Takayuki
, p. 4211 - 4214 (2007/10/03)
Vibsanol (1), a benzofuran-type lignan isolated from the wood of Viburnum awabuki (Caprifoliaceae), was synthesized by the tandem cyclization of o-tert-butyldimethylsiloxydiarylalkyne with tetrabutylammonium fluoride and excess paraformaldehyde as the key step.
