86219-77-4Relevant articles and documents
Oxidation reactions of azines. 10. Synthesis, structure, and oxodihydroxylation of 3-hydroxymethyl-1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Soldatenkov,Temesgen,Polyanskii,Soldatova,Kolyadina,Golovtsov,Sergeeva
, p. 471 - 477 (2007/10/03)
It has been established that oxidation of a mixture of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and dicyanomethane or formaldehyde with manganese dioxide gives 3-hydroxymethyl-1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, the structure of which was confirmed by X-ray structural analysis. Some oxidative conversions by potassium permanganate of the product formed and its esters have been studied. These included lactamization, aromatization, and oxodihydroxylation.
Isolation and Structure Elucidation of the By-Product Formed in the Aminomethylation of α-Methylstyrene
Sohar, Pal,Lazar, Janos,Bernath, Gabor
, p. 551 - 559 (2007/10/02)
Aminomethylation of α-Methylstyrene (1) leads to 1,2,3,6-tetrahydro-4-phenylpyridine (3) as main product, together with a significant amount of a previously unknown by-product.The N-methyl, O-acetyl-N-methyl, N,O-diacetyl, N-(4-nitrobenzoyl), and (via N -> O acyl-migration) O-(4-nitrobenzoyl) derivatives of the by-product were synthesized.By aromatization of the heteroring, 4-phenyl-3-pyridinemethanol (8a) was obtained.According to these derivatives and their IR, 1H and 13C NMR spectra, the by-product is 1,2,3,6-tetrahydro-4-phenyl-3-pyridine-methanol (4a).