862249-74-9Relevant academic research and scientific papers
Carboxylic Acid Compounds and Use Thereof
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Page/Page column 81, (2010/11/28)
Provision of a superior URAT1 activity inhibitor effective for the treatment and the like of a pathology involving uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urinary lithiasis, renal dysfunction, coronary heart disease, ischemic cardiac diseases and the like. A URAT1 activity inhibitor containing a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate thereof as an active ingredient: [image] wherein each symbol is as defined in the specification.
Microwave-assisted one-pot regioselective synthesis of 2-alkyl-3,4-dihydro- 3-oxo-2H-1,4-benzoxazines
Dai, Wei-Min,Wang, Xuan,Ma, Chen
, p. 6879 - 6885 (2007/10/03)
A protocol for regioselective one-pot synthesis of 2-alkyl-3,4-dihydro-3- oxo-2H-1,4-benzoxazines under controlled microwave heating has been developed. Starting from commercially available 2-aminophenols, a base-mediated regioselective O-alkylation took
