862260-91-1Relevant academic research and scientific papers
Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold
Tsou, Lun K.,Dutschman, Ginger E.,Gullen, Elizabeth A.,Telpoukhovskaia, Maria,Cheng, Yung-Chi,Hamilton, Andrew D.
, p. 2137 - 2139 (2010)
A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4]arene scaffold that possesses dual inhibition for both HIV and HCV is described. Structural activity relationship studies demonstrate the effects of lower-rim alkylation in maintaining cone conformation and upper-rim interacting head groups on the calix[4]arene play key roles for its potent dual antiviral activities.
Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation
Zhou, Huchen,Wang, De-An,Baldini, Laura,Ennis, Eileen,Jain, Rishi,Carie, Adam,Sebti, Said M.,Hamilton, Andrew D.
, p. 2376 - 2386 (2008/09/19)
Platelet-derived growth factor (PDGF) and its receptor PDGFR are required for tumor growth and angiogenesis, so disruption of the PDGF-PDGFR interaction should lead to starvation of tumors and reduction of tumor growth. Potent PDGF antagonists have been discovered through the synthesis of a series of calix[4]arene-based compounds that are designed to bind to the three-loop region of PDGF. The effect of lower-rim alkylation, linker and number of interacting head groups on the calix[4]arene scaffold on PDGF affinity and cellular activity has been investigated. The Royal Society of Chemistry 2006.
