862280-33-9Relevant academic research and scientific papers
Caprolactams as potent CGRP receptor antagonists for the treatment of migraine
Shaw, Anthony W.,Paone, Daniel V.,Nguyen, Diem N.,Stump, Craig A.,Burgey, Christopher S.,Mosser, Scott D.,Salvatore, Christopher A.,Rutledge, Ruth Z.,Kane, Stefanie A.,Koblan, Kenneth S.,Graham, Samuel L.,Vacca, Joeseph P.,Williams, Theresa M.
, p. 4795 - 4798 (2007)
Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Replacements for the benzodiazepine core of an earlier lead structure 1 including 5-, 6-, and 7-membered lactams were explored. Within the 7-membered ring scaffold
