862298-48-4Relevant articles and documents
((11-OXO-10,11-DIHYDRODIBENZO [B, F] [1, 4] OXAZEPIN-1-YL)OXY) ACETIC ACID DERIVATIVES AND RELATED COMPOUNDS AS CARDIOVASCULAR PREPARATIONS USED TO TREAT ARTERIOLOSCLEROSIS
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Page/Page column 34, (2010/02/13)
The invention relates to dibenzoxazepines and to a method for the production thereof, use thereof in the treatment and/or prophylaxis of illnesses, in addition to the use thereof in the production of medicaments for treating and/or for the prophylaxis of diseases, in particular cardiovascular illnesses, e.g. arteriolosclerosis, and cancers: Said dibenzoxazepines are represented by formula (I), wherein R2 represents C1-C6-alkyl, alkyl can be substituted by 1 or 2 substituents, said substituents are selected independently from each other from the group consisting of halogen, hydroxy, oxo, C1-C6-alkoxy, hydroxycarbonyl, C1-C6-alkoxycarbonyl, aminocarbonyl and C1-C6-alkylaminocarbonyl, R3 represents O-CH2CO2H or -O-(CH2)2CO2H, R5 represents 5- 10-membered heteroaryl, -SO2-R6 or -NR7(C=O)R8, whereby heteroaryl can be substituted by 1, 2 or 3 substituents, said substituents being selected independently from each other from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, C1-C6 alkylamino, hydroxy, C1-C6-alkyl, C1-C6-aIkoxy, hydroxycarbonyl, C1-C6-alkoxycarbonyl, amino-carbonyl, C1-C6-alkylaminocarbonyl, C6-C10-aryl and C3-C8-aycloalkyl. The other substituents are defined in the claims.