862377-31-9 Usage
Description
(2R,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol is a complex organic compound with a unique molecular structure. It is characterized by its hexahydro-2H-benzo[a]quinolizin-2-ol backbone, which features a 2-methylpropyl group at the 3-position and methoxy groups at the 9 and 10 positions. (2R,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol is an enantiomer of (2S,3R,11bS)-Dihydrotetrabenazine (D454920) and is related to Tetrabenazine and its derivatives.
Uses
Used in Pharmaceutical Industry:
(2R,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol is used as a potent inhibitor of vesicular monoamine transporter 2 (VMAT2) for the treatment of various diseases such as Huntington's disease and other hyperkinetic disorders. Its ability to inhibit VMAT2 makes it a potential drug candidate for managing symptoms associated with these conditions.
Used in Drug Development:
As a derivative of Tetrabenazine, (2R,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol is utilized in drug development research to explore its potential as a therapeutic agent. Its unique structure and properties may offer new avenues for the treatment of neurological disorders and other conditions that could benefit from VMAT2 inhibition.
Check Digit Verification of cas no
The CAS Registry Mumber 862377-31-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,2,3,7 and 7 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 862377-31:
(8*8)+(7*6)+(6*2)+(5*3)+(4*7)+(3*7)+(2*3)+(1*1)=189
189 % 10 = 9
So 862377-31-9 is a valid CAS Registry Number.
862377-31-9Relevant articles and documents
Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors
Yao, Zhangyu,Wei, Xueying,Wu, Xiaoming,Katz, Jonathan L.,Kopajtic, Theresa,Greig, Nigel H.,Sun, Hongbin
, p. 1841 - 1848 (2011/05/07)
Tetrabenazine (TBZ) ((±)-1) and dihydrotetrabenazines (DHTBZ) are potent inhibitors of VMAT2. Herein, a practical chemical resolution of (±)-1 and stereoselective synthesis of all eight DHTBZ stereoisomers are described. The result of VMAT2 binding assay revealed that (+)-1 (Ki = 4.47 nM) was 8000-fold more potent than (-)-1 (Ki = 36,400 nM). Among all eight DHTBZ stereoisomers, (2R,3R,11bR)-DHTBZ ((+)-2: Ki = 3.96 nM) showed the greatest affinity for VMAT2. The (3R,11bR)-configuration appeared to play a key role for VMAT2 binding. In summary, (+)-1, (+)-2, and their derivatives warrant further studies in order to develop more potent and safer drugs for the treatment of chorea associated with Huntington's disease and other hyperkinetic disorders.
3 , llB-CIS-DIHYDROTETRABENAZINE FOR THE TREATMENT OF A PROLIFERATIVE DISEASE OR AN INFLAMMATION
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Page/Page column 39-41, (2008/06/13)
The invention provides the use of a compound for the manufacture of a medicament for the prophylaxis or treatment of a proliferative disease or an inflammatory disease, the compound being 3,1lb-cis-dihydrotetrabenazine or a pharmaceutically acceptable sal
