86239-02-3

Upstream product

• 3556-83-0 methyl 4-methyl-3-methoxybenzoate 
• 86239-03-4 ethyl 3-methoxy-4-methylbenzoate 

Downstream Products

• 86238-87-1 diethyl (4-carbethoxy-2-methoxybenzyl)phosphonate 
• 86238-77-9 (E)-1-(4-carbethoxy-2-methoxyphenyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butadiene 
• 86238-78-0 (E)-1-(4-carboxy-2-methoxyphenyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butadiene 
• 86238-94-0 (E)-3-(4-carbethoxy-2-methoxyphenyl)-2-methylpropenal 
• 86238-89-3 1-(4-carbethoxy-2-methoxyphenyl)-2-methylpropene 

Relevant academic research and scientific papers

Aromatic retinoic acid analogues

Aromatic retinoic acid analogues of the formula STR1 where X is hydrogen or fluorine, Y is hydrogen, halogen of atomic number 9 or 17, hydroxy, alkyl of 1 to 2 carbon atoms or alkoxy of 1 to 2 carbon atoms and R is hydroxy, alkoxy, aroxy, or NR 1 R 2 where R 1 is hydrogen, alkyl, or aryl and R 2 is alkyl or aryl, with the proviso that when Y is hydrogen, X is fluorine. These retinoids are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.

Aromatic Retinoic Acid Analogues. 2. Synthesis and Pharmacological Activity

Aromatic analogues of (E)-1-(4-carboxyphenyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butadiene (1b) and its ethyl ester (1a) were synthesized as potential chemopreventive agents for the treatment of epithelial cancer and such skin diseases as psoriasis and cystic acne.The phenyl ring of 1 was replaced by 2-fluorophenyl, 2-methoxyphenyl, thienyl, furanyl, and pyridyl groups.The 1-fluorobutadiene analogue of 1 was also synthesized.With exception for the furanyl analogue, these compounds demonstrated good activity in reversing keratinization in hamster tracheal organ culture and in inhibiting the induction of ornithine decarboxylase in mouse epidermis by a tumor promoter.