862404-76-0

Upstream product

• 2978-10-1 N,N'-diisopropyl-O-benzyl isourea 
• 5241-64-5 BOC-tryptophane 

Downstream Products

• 862403-09-6 (RS)-2-t-butoxycarbonylamino-3-[1-(4-t-butylbenzyl)-1H-indol-3-yl]propionic acid benzyl ester 
• 862403-17-6 (RS)-2-t-butoxycarbonylamino-3-[1-(3,4-difluorobenzyl)-1H-indol-3-yl]propionic acid benzyl ester 
• 862403-05-2 2-t-butoxycarbonylamino-3-(1-pentyl-1H-indol-3-yl)propionic acid benzyl ester 
• 862403-13-2 (RS)-2-t-butoxycarbonylamino-3-[1-(4-cyanobenzyl)-1H-indol-3-yl]propionic acid benzyl ester 
• 393568-31-5 (R)-3-(1-Benzyl-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionic acid benzyl ester 

Relevant academic research and scientific papers

Polymer-supported O-alkylisoureas: Useful reagents for the O-alkylation of carboxylic acids

Polymer-supported O-alkylisoureas were prepared by reaction of an alcohol with a polymer-supported carbodiimide under copper(II) catalysis. These reagents were used to transform carboxylic acids into the corresponding methyl, benzyl, allyl, and p-nitrobenzyl esters in a highly chemoselective manner in high yields and in very high purity after simple resin filtration and solvent evaporation. The reactions could be carried out using both conventional or microwave heating, with reaction times as short as 3-5 min in the latter case, without compromising yield, purity, or chemoselectivity. Unfortunately, the corresponding solid-supported tert-butyl isoureas could not be prepared.

Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas

(equation presented) Microwave-assisted O-alkylations of several carboxylic acids have been performed with three different O-alkylisoureas. All reactions are significantly faster compared to conventionally heated reactions, while retaining high chemoselec