862416-33-9

Usage

Uses

Used in Pharmaceutical Research:
1-BENZYL-3,3-DIFLUORO-PYRROLIDINE-2,5-DIONE is used as a building block for the synthesis of various organic compounds and drug molecules. Its distinctive structure allows it to be a valuable component in the development of new pharmaceuticals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-BENZYL-3,3-DIFLUORO-PYRROLIDINE-2,5-DIONE is utilized for its potential biological activities. Its specific structural features may contribute to the discovery and design of novel therapeutic agents.
Further research and analysis are necessary to fully elucidate the properties and potential applications of 1-BENZYL-3,3-DIFLUORO-PYRROLIDINE-2,5-DIONE, ensuring its optimal use in these industries.

Upstream product

• 100-46-9 benzylamine 
• 862416-30-6 4-(benzylamino)-3,3-difluoro-4-oxobutanoic acid 

Relevant academic research and scientific papers

PURINE DERIVATIVES

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, G, ring A, ring B, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, and m are defined herein. The novel purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Synthesis of Small 3-Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry

Here, we report accessing small 3-fluoropyrrolidines and 3,3-difluoropyrrolidines through a 1,3-dipolar cycloaddition with a simple azomethine ylide and a variety of vinyl fluorides and vinyl difluorides. We demonstrate that vinyl fluorides within α,β-unsaturated, styrenyl and even enol ether systems can participate in the cycloaddition reaction. The vinyl fluorides are relatively easy to synthesize through a variety of methods, making the 3-fluoropyrrolidines very accessible.

Practical preparation of 3,3-difluoropyrrolidine

A practical and cost-effective synthesis of 3,3-difluoropyrrolidine is reported. The synthesis involves the isolation of two intermediates, which are prepared via two efficient through processes: (1) a Claisen rearrangement followed by a Ru(VIII)-catalyzed oxidation to prepare the 2,2-difluorosuccinic acid and (2) an efficient cyclization to form N-benzyl-3,3-difluoropyrrolidinone followed by BH3·Me2S reduction.