862458-01-3

Basic information

• Product Name: ethyl 4,4-difluoro-3-phenyl-butanoate
• Synonyms: 4,4-Difluoro-3-phenyl-butyric acid ethyl ester; benzenepropanoic acid, β-(difluoromethyl)-, ethyl ester; Ethyl 4,4-difluoro-3-phenylbutanoate
• CAS NO: 862458-01-3
• Molecular Formula: C₁₂H₁₄F₂O₂
• Molecular Weight: 228.2352
• Mol File: 862458-01-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 256.9°C at 760 mmHg
• Flash Point: 106°C
• Density: 1.12g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.465
• CAS DataBase Reference: ethyl 4,4-difluoro-3-phenyl-butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4,4-difluoro-3-phenyl-butanoate(862458-01-3)
• EPA Substance Registry System: ethyl 4,4-difluoro-3-phenyl-butanoate(862458-01-3)

Safety Data

• Hazardous Substances Data: 862458-01-3(Hazardous Substances Data)

Upstream product

• 395-01-7 2,2-difluoro-1-phenylethanone 
• 1610-04-4 α-bromo-α,α-difluoro-acetophenone 
• 862457-96-3 (E)-ethyl 4-bromo-4,4-difluoro-3-phenyl-2-butenoate 
• 852561-60-5 ethyl 3-phenyl-4,4-difluoro-3-butenoate 

Relevant articles and documents

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The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods of use thereof.

Stereocontrolled synthesis of β-difluoromethylated materials

Investigation of synthetic routes for regio- and stereocontrolled fluorinated materials with a difluoromethyl group, using ethyl bromodifluoroacetate as a starting material, is described. In particular, (E)-difluoromethylated trisubstituted olefins were p