862463-94-3Relevant academic research and scientific papers
An iterative catalytic route to enantiopure deoxypropionate subunits: Asymmetric conjugate addition of Grignard reagents to α,β-unsaturated thioesters
Des Mazery, Renaud,Pullez, Maddalena,Lopez, Fernando,Harutyunyan, Syuzanna R.,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 9966 - 9967 (2007/10/03)
A highly enantioselective (up to 96% ee) conjugate addition of Grignard reagents, in particular, MeMgBr, to α,β-unsaturated thioesters is provided as well as its application to a diastereo- and enantioselective iterative route to syn- and anti-1,3-dimethyl arrays and deoxypropionate subunits. The versatility of the method is illustrated in the synthesis of (-)-lardolure, a multimethyl-branched insect natural pheromone. Copyright
