862473-36-7

Upstream product

• 2812-46-6 proline tert-butyl ester 
• 862473-40-3 Fmoc-L-Lys(Cbz)-Pro-OBu^t 
• 86060-82-4 Fmoc-Lys(Z)-OH 
• 88555-03-7 (2S,2'S)-1-(2'-amino-6'-benzyloxycarbonylamino-hexanoyl)-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 862473-33-4 (2S,2'S,3''S,4''S,2'''S)-1-(6'-benzyloxycarbonylamino-2'-{3''-[3'''-tert-butoxy-2'''-(9H-fluoren-9''''-ylmethoxycarbonylamino)-propionylamino]-2''-oxo-4''-vinyl-piperidin-1''-yl}-hexanoyl)-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 862473-24-3 (4S,1'S,1'''S,2''''S)-4-(1'-{2''-[[5'''-benzyloxycarbonylamino-1'''-(2''''-tert-butoxycarbonyl-pyrrolidine-1''''-carbonyl)-pentyl]-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-ethyl}-allyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester 
• 862473-25-4 (2S,2'S,3''S,2'''S)-1-{6'-benzyloxycarbonylamino-2'-[[3'''-(tert-butoxycarbonylamino-carboxy-methyl)-pent-4'''-enyl]-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-hexanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 862473-34-5 (2S,2'S,3''S,4''S,2'''S)-1-{2'-[3''-(2'''-amino-3'''-tert-butoxy-propionylamino)-2''-oxo-4''-vinyl-piperidin-1''-yl]-6'-benzyloxycarbonylamino-hexanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 862473-23-2 (4S,1'S,1'''S,2''''S)-4-(1'-{2''-[5'''-benzyloxycarbonylamino-1'''-(2''''-tert-butoxycarbonyl-pyrrolidine-1''''-carbonyl)-pentylamino]-ethyl}-allyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 862473-26-5 (2S,2'S,3''S,4''S)-1-[6'-benzyloxycarbonylamino-2'-(3''-tert-butoxycarbonylamino-2''-oxo-4''-vinyl-piperidin-1''-yl)-hexanoyl]-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 862473-27-6 (2S,2'S,3''S,4''S)-1-[2'-(3''-amino-2''-oxo-4''-vinyl-piperidin-1''-yl)-6'-benzyloxycarbonylamino-hexanoyl]-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 862473-35-6 (2S,2'S,3''S,4''S,2'''S)-1-{2'-[3''-(2'''-acetylamino-3'''-tert-butoxy-propionylamino)-2''-oxo-4''-vinyl-piperidin-1''-yl]-6'-benzyloxycarbonylamino-hexanoyl}-pyrrolidine-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of 4-substituted-3-aminopiperidin-2-ones: Application to the synthesis of a conformationally constrained tetrapeptide N-acetyl-Ser-Asp-Lys- Pro

A new and practical synthetic strategy is developed for the synthesis of six-membered lactam-bridged dipeptides, 4-substituted-3-aminopiperidin-2-ones, featuring two key steps: (a) a diastereoselective addition of cuprate to (E)-α,β-unsaturated ester (3)