862509-80-6

Basic information

• Product Name: (2S,3R,4R)-2,3-bis-(p-methoxybenzyloxy)-4-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanal
• Synonyms: (2S,3R,4R)-2,3-bis-(p-methoxybenzyloxy)-4-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanal
• CAS NO: 862509-80-6
• Molecular Weight: 622.756
• Mol File: 862509-80-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3R,4R)-2,3-bis-(p-methoxybenzyloxy)-4-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanal(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R,4R)-2,3-bis-(p-methoxybenzyloxy)-4-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanal(862509-80-6)
• EPA Substance Registry System: (2S,3R,4R)-2,3-bis-(p-methoxybenzyloxy)-4-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanal(862509-80-6)

Safety Data

• Hazardous Substances Data: 862509-80-6(Hazardous Substances Data)

Upstream product

• 862509-74-8 methyl (2S,3R,4R)-2,3-dihydroxy-4-[5-(R)-hydroxy-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanoate 
• 194934-59-3 methyl (2S,3R,4R)-4-[5-(R)-benzyloxy-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-2,3-dihydroxy-pentanoate 
• 194934-52-6 methyl (2E,4R)-4-[5-(R)-benzyloxy-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pent-2-enoate 
• 194934-58-2 (S)-2-[5-(R)-benzyloxy-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-propionaldehyde 
• 862509-84-0 (4R,5R,6R)-5-benzyloxy-4-[1-hydroxy-prop-2-(R)-yl]-2,2,6-trimethyl-1,3-dioxane 
• 392692-55-6 methyl (2S,3R,4R)-2,3-bis-(p-methoxybenzyloxy)-4-[5-(R)-(p-methoxybenzyloxy)-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-pentanoate 

Downstream Products

• 392692-62-5 (1S,4S,5R,6R)-10-chloro-4-hydroxy-1-(p-methoxybenzyloxy)-1-[4,5-(R,R)-bis(p-methoxybenzyloxy)-3-(R)-methyl-6-(R)-(2-methylallyl)-tetrahydropyran-2-(R)-yl]-5-methyl-6-(triethylsiloxy)-decan-2-one 
• 392692-58-9 C₄₉H₆₇BO₈ 
• 862509-81-7 (2R,3R,4R,5R,6R)-6-[2-(R)-hydroxy-1-(R)-(p-methoxybenzyloxy)-prop-1-yl]-3,4-bis(p-methoxybenzyloxy)-5-methyl-2-(2-methylallyl)-tetrahydropyran 
• 392692-57-8 (S)-1-[(2R,3R,4R,5R,6R)-4,5-Bis-(4-methoxy-benzyloxy)-3-methyl-6-(2-methyl-allyl)-tetrahydro-pyran-2-yl]-1-(4-methoxy-benzyloxy)-propan-2-one 
• 392692-54-5 1-[(2R,3R,4R,5R,6R)-6-[(1R,2R)-2-Hydroxy-1-(4-methoxy-benzyloxy)-propyl]-3,4-bis-(4-methoxy-benzyloxy)-5-methyl-tetrahydro-pyran-2-yl]-propan-2-one 

Relevant articles and documents

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: The southern hemisphere EF segment

The fully functionalised C29-C51 southern hemisphere of altohyrtin A/spongistatin 1 (1), incorporating the E- and F-ring tetrahydropyran rings and the unsaturated side chain, has been synthesised in a highly convergent and stereocontrolled manner. Key steps in the synthesis of this phosphonium salt include four highly diastereoselective, substrate-controlled, boron aldol reactions to establish key C-C bonds and accompanying stereocentres, where the introduction of the chlorodiene side chain and the C47 hydroxyl-bearing centre were realised by exploiting remote stereoinduction from the F-ring tetrahydropyran. The Royal Society of Chemistry 2005.