862541-23-9Relevant academic research and scientific papers
IN VIVO IMAGING COMPOUNDS
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, (2009/07/03)
The invention relates to a compound of formula (I) having use for in vivo imaging of the NR2B subtype of the NMDA receptor. [image]
Aminoacetamide acyl guanidines as beta-secretase inhibitors
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Page/Page column 18, (2008/06/13)
There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R2, R3, R4, R5, R25, R26 and R27 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
Sulfonamide derivatives for the treatment of diseases
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Page/Page column 36, (2008/06/13)
The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in
