862549-37-9Relevant academic research and scientific papers
Polar 3-alkylidene-5-pivaloyloxymethyl-5′-hydroxymethyl-γ-lactones as protein kinase C ligands and antitumor agents
Kang, Ji-Hye,Kim, Yerim,Won, Shin-Hye,Park, Song-Kyu,Lee, Chang Woo,Kim, Hwan-Mook,Lewin, Nancy E.,Perry, Nicholas A.,Pearce, Larry V.,Lundberg, Daniel J.,Surawski, Robert J.,Blumberg, Peter M.,Lee, Jeewoo
, p. 1008 - 1012 (2010)
A series of DAG-lactones with polar 3-alkylidene substituents have been investigated as PKC-α ligands and antitumor agents. Extensive analysis of structure-activity relationships for the 3-alkylidene chain revealed that polar groups such as ether, hydroxy
GLYCEROL COMPOUNDS AND METHODS OF USE
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, (2022/04/03)
Provided herein, inter alia, are compounds of fatty acid glycerol derivatives and compositions including the same.
DIACYLGLYCEROL LACTONE COMPOUND, PREPARATION METHOD THEREFOR, AND IMMUNOSTIMULATOR CONTAINING SAME AS ACTIVE INGREDIENT
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Paragraph 0034; 0039, (2021/01/26)
Disclosed are a novel diacylglycerol lactone compound for improving immunity and inhibiting infection by promoting neutrophil movement, a preparation method therefor, and an immunostimulator containing same as an active ingredient. The diacyloglycerol lactone compound is represented by chemical formula 1 of the specification. In chemical formula 1, R1 and R2 are respectively N and independently a C2-30 fatty acid group.
Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C
Kang, Ji-Hye,Peach, Megan L.,Pu, Yongmei,Lewin, Nancy E.,Nicklaus, Marc C.,Blumberg, Peter M.,Marquez, Victor E.
, p. 5738 - 5748 (2007/10/03)
Diacylglycerol (DAG) lactones with altered functionality (C=O → CH2 or C=O → C=S) at the sn-1 and sn-2 carbonyl pharmacophores were synthesized and used as probes to dissect the individual role of each carbonyl in the binding to protein kinase
