862555-23-5

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 20955-94-6 1-[(4-chlorophenyl)methyl]-1-(4-methoxyphenyl)-hydrazine hydrochloride 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 15118-53-3 2,2-dimethyl-4-oxohexanoic acid 
• 103253-35-6 3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid 
• 148693-70-3 methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate 
• 269410-15-3 2-(2-fluoro-[1,1'-biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 862555-21-3 3-[1-(4-chloro-benzyl)-3-methyl-5-trifluoromethanesulfonyloxy-1H-indol-2-yl]-2,2-dimethyl-propionic acid methyl ester 

Relevant academic research and scientific papers

Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886

A series of potent and selective inhibitors of the inducible microsomal PGE2 synthase (mPGES-1) has been developed based on the indole FLAP inhibitor MK-886. Compounds 23 and 30 inhibit mPGES-1 with potencies in the low nanomolar range and with selectivities of at least 100-fold compared to their inhibition of mPGES-2, thromboxane synthase and binding affinity to FLAP. They also block the production of PGE2 in cell based assays but with a decreased potency and more limited selectivity compared to the enzyme assays.