862682-81-3Relevant academic research and scientific papers
Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode
Finlay, M. Raymond V.,Acton, David G.,Andrews, David M.,Barker, Andrew J.,Dennis, Michael,Fisher, Eric,Graham, Mark A.,Green, Clive P.,Heaton, David W.,Karoutchi, Galith,Loddick, Sarah A.,Morgentin, Remy,Roberts, Andrew,Tucker, Julie A.,Weir, Hazel M.
, p. 4442 - 4446 (2008)
A piperazine series of cyclin-dependent kinase (CDK) inhibitors have been identified. The compounds exhibit excellent physiochemical properties and a novel binding mode, whereby a bridging interaction via a water molecule with Asp 86 of CDK2, leads to sel
IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION
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Page/Page column 53, (2010/02/13)
Compounds of the formula (I), wherein variable groups are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti cell proliferation) effect in a warm blooded animal, such as man.
