862683-97-4Relevant academic research and scientific papers
Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode
Finlay, M. Raymond V.,Acton, David G.,Andrews, David M.,Barker, Andrew J.,Dennis, Michael,Fisher, Eric,Graham, Mark A.,Green, Clive P.,Heaton, David W.,Karoutchi, Galith,Loddick, Sarah A.,Morgentin, Remy,Roberts, Andrew,Tucker, Julie A.,Weir, Hazel M.
scheme or table, p. 4442 - 4446 (2009/04/06)
A piperazine series of cyclin-dependent kinase (CDK) inhibitors have been identified. The compounds exhibit excellent physiochemical properties and a novel binding mode, whereby a bridging interaction via a water molecule with Asp 86 of CDK2, leads to sel
IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION
-
Page/Page column 66, (2010/02/13)
Compounds of the formula (I), wherein variable groups are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti cell proliferation) effect in a warm blooded animal, such as man.
