862728-59-4

Basic information

• Product Name: Ethanol, 2-(cyclopropyloxy)-, 4-methylbenzenesulfonate
• Synonyms: Ethanol, 2-(cyclopropyloxy)-, 4-methylbenzenesulfonate ;Toluene-4-Sulfonic Acid 2-Cyclopropoxy-Ethyl Ester;Toluene-4-Sulfonic Acid 2-Cyclopropoxy-Ethyl Ester(WX690207)
• CAS NO: 862728-59-4
• Molecular Formula: C₁₂H₁₆O₄S
• Molecular Weight: 256.31804
• Mol File: 862728-59-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanol, 2-(cyclopropyloxy)-, 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-(cyclopropyloxy)-, 4-methylbenzenesulfonate(862728-59-4)
• EPA Substance Registry System: Ethanol, 2-(cyclopropyloxy)-, 4-methylbenzenesulfonate(862728-59-4)

Safety Data

• Hazardous Substances Data: 862728-59-4(Hazardous Substances Data)

Upstream product

• 18742-02-4 2-bromo-2-(2-ethyl)dioxolane 
• 20117-44-6 2-(cyclopropyloxy)ethan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1358579-72-2 [(1S,2S,3S,4R,5S)-2,3,4-tri-benzyloxy-5-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6,8-dioxabicyclo[3.2.1]octan-1-yl]methanol 
• 1358579-69-7 [(3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-(hydroxymethyl)-6-methoxytetrahydropyran-2-yl]methanol 
• 1358579-67-5 (2S,3S,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-formaldehyde 
• 1358579-65-3 [(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methanol 
• 1358579-61-9 tert-butyldimethyl-[[(2R,3R,4S,5R,6S)-3,4,5-tri-benzyloxy-6-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-methoxytetrahydropyran-2-yl]methoxy]silicon 
• 1358579-58-4 (2S,3R,4S,5S,6R)-6-[[tert-butyl(dimethyl)silyloxy]methyl]-2-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-2-methoxytetrahydropyran-3,4,5-triol 
• 1118567-46-6 (2S,3R,4S,5S,6R)-2-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-6-(hydroxymethyl)-2-methoxytetrahydropyran-3,4,5-triol 
• 1400980-44-0 1-chloro-2-(4-(2-cyclopropoxyethoxy)benzyl)-4-iodobenzene 
• 1118567-05-7 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 1118567-45-5 4-bromo-1-chloro-2-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]benzene 

Relevant articles and documents

Discovery of a Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor (HSK0935) for the Treatment of Type 2 Diabetes

A new class of potent and highly selective SGLT2 inhibitors is disclosed. Compound 31 (HSK0935) demonstrated excellent hSGLT2 inhibition of 1.3 nM and a high hSGLT1/hSGLT2 selectivity of 843-fold. It showed robust urinary glucose excretion in Sprague-Dawley (SD) rats and affected more urinary glucose excretion in Rhesus monkeys. Finally, an efficient synthetic route has been developed featuring a ring-closing cascade reaction to incorporate a double ketal 1-methoxy-6,8-dioxabicyclo[3.2.1]octane ring system.

PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES

Methods for preparing intermediates of SGLT2 inhibitors are provided, including crystalline forms and methods of crystallizing intermediates.

PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES

Methods for preparing intermediates of SGLT2 inhibitors are provided, including crystalline forms and methods of crystallizing intermediates.