862816-08-8

Basic information

• Product Name: 1H-Pyrazole-3-carboxaldehyde, 5-(4-methoxyphenyl)-
• CAS NO: 862816-08-8
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.213
• Mol File: 862816-08-8.mol

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-3-carboxaldehyde, 5-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3-carboxaldehyde, 5-(4-methoxyphenyl)-(862816-08-8)
• EPA Substance Registry System: 1H-Pyrazole-3-carboxaldehyde, 5-(4-methoxyphenyl)-(862816-08-8)

Safety Data

• Hazardous Substances Data: 862816-08-8(Hazardous Substances Data)

Upstream product

• 1192020-79-3 (3-(4-methoxyphenyl)-1H-pyrazol-5-yl)methanol 
• 938182-54-8 ethyl 5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate 
• 35322-20-4 ethyl 3-(4-methoxybenzoyl)pyruvate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 862816-10-2 2-(4-methoxyphenyl)-pyrazole[1,5-d][1,2,4]triazine 
• 1137165-43-5 ethyl 2-(4-methoxyphenyl)pyrazolo[1,5-a]pyridine-5-carboxylate 
• 1137165-44-6 ethyl 2-(4-methoxyphenyl)-6-methylpyrazolo[1,5-a]pyridine-5-carboxylate 

Relevant articles and documents

Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents

As pyrazole and isoxazole based derivatives are well-known for displaying a considerable biological profile, an attempt has been made to unravel their cytotoxic potential. In this context, a number of pyrazole/isoxazole linked arylcinnamide conjugates (15

Synthesis, Characterization and biological applications of pyrazole-benzothiazolamine conjugates

Present paper describes the synthesis of some new pyrazole-benzothiazolamine conjugates by molecular conjunction by adopting appropriate synthetic routes. Purification of intermediates and final compounds has been done by recrystallization and chromatographic techniques. Characterization of all the newly synthesized pyrazole-benzothiazolamine derivatives was done by physical and spectral data. The experimental procedure for the preparation of seventeen pyrazole-benzthiazolamine conjugates has been incorporated. Data of synthesized compounds like IR, 1H NMR and Mass spectra were neatly presented. All these compounds were evaluated for their activity against Gram-positive and Gram-negative bacteria and various fungal strains. Anticancer activity has been carried out for the synthesized compounds using HeLa, DU145 and A549 cell lines using MTT assay and we found that the pyrazole-benzothiazolamine conjugates were possess antimicrobial, antifungal and anticancer activities.

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A novel and efficient approach to pyrazolo[1,5-a]pyridine derivatives via one-pot tandem reaction

An unusual intramolecular condensation of a, α,β-unsaturated esters with aldehydes was discovered and the pyrazolo[1,5-α]pyridine derivatives were conveniently synthesized by this novel tandem reaction under very mild conditions. The reaction mechanism was also proposed.

NITROGENOUS FUSED HETEROAROMATIC RING DERIVATIVE

The invention provides a compound or its pharmaceutically-acceptable salt of formula (I): wherein A1 is a hydrogen, etc.; j and k are 0 or 1; is a double bond, etc.; is a double bond, etc.; one of W1 and W2 is E-O-W, etc., and the other is a hydrogen atom, etc.; E is a divalent group derived from a benzene ring, etc., by removing two hydrogen atoms therefrom; W is a group of formula (II-1): which has a histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect and is useful for prevention or remedy of metabolic system diseases, circulatory system diseases or nervous system diseases.