862819-80-5

Upstream product

• 917-54-4 methyllithium 
• 336607-98-8 (S)-(-)-1-[1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione 
• 105779-71-3 (S)-(-)-[2-(3,4-dimethoxyphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester 
• 138908-56-2 (S)-(+)-2-tert-butoxycarbonylamino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester 
• 336607-96-6 (S)-(-)-1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethylamine 
• 336607-94-4 (S)-(-)-[1-(tert-butyldiphenylsilyloxymethyl)-2-(3,4-dimethoxyphenyl)ethyl]carbamic acid tert-butyl ester 
• 32161-30-1 (S)-3,4-dimethoxyphenylalanine 
• 127095-97-0 (2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,4-dimethoxyphenyl)propanoic acid 

Relevant academic research and scientific papers

Diastereoselective intramolecular α-amidoalkylation reactions of L-DOPA derivatives. Asymmetric synthesis of pyrrolo[2,1-a]isoquinolines

Stereocontrolled intramolecular α-amidoalkylation reactions of L-DOPA-derived succinimides have been studied. Addition of MeLi to nonracemic succinimides 9a-d yields oxoamides, which are cyclized upon treatment with Lewis or protic acids to afford (5S,10b

Enantioselective synthesis of pyrrolo[2,1-a]isoquinolones via stereocontrolled N-acyliminium ion cyclisations

Stereocontrolled N-acyliminium ion cyclisation of L-DOPA derived succinimide 5 has been investigated. Addition of organolithiums to chiral non-racemic 5 yields oxoamides, which are cyclised diastereoselectively upon treatment with BF3·OEt2, to afford 5,10b-trans pyrroloisoquinolones in moderate yields and high ee (99%).