862822-08-0Relevant academic research and scientific papers
Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents
Yoshida, Masao,Hayakawa, Ichiro,Hayashi, Noriyuki,Agatsuma, Toshinori,Oda, Youko,Tanzawa, Fumie,Iwasaki, Shiho,Koyama, Kumiko,Furukawa, Hidehiko,Kurakata, Shinichi,Sugano, Yuichi
, p. 3328 - 3332 (2007/10/03)
Based on 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2- (cyclohexanecarbonylamino)benzothiazol-6-yl]amide (1), which shows selective cytotoxicity against tumorigenic cell lines, 2,6-dichloro-N-[2- (cyclopropanecarbonylamino)benzothiazol-6-yl]benzamide (13b) was designed and synthesized as a biologically stable derivative containing no nitro group. The highly potent derivative 13b exhibited excellent in vivo inhibitory effect on tumor growth.
