862847-50-5Relevant academic research and scientific papers
Phase-transfer-catalyzed asymmetric SNAr reaction of ?±-amino acid derivatives with arene chromium complexes
Shirakawa, Seiji,Yamamoto, Kenichiro,Maruoka, Keiji
supporting information, p. 838 - 840 (2015/02/18)
Although phase-transfer-catalyzed asymmetric SNAr reactions provide unique contribution to the catalytic asymmetric ?±-arylations of carbonyl compounds to produce biologically active ?±-aryl carbonyl compounds, the electrophiles were limited to arenes bearing strong electron-withdrawing groups, such as a nitro group. To overcome this limitation, we examined the asymmetric SNAr reactions of aamino acid derivatives with arene chromium complexes derived from fluoroarenes, including those containing electron-donating substituents. The arylation was efficiently promoted by binaphthyl-modified chiral phase-transfer catalysts to give the corresponding ?±,?±-disubstituted ?±-amino acids containing various aromatic substituents with high enantioselectivities.
Exploring new dipeptides based on phenylglycine and Cα- methyl phenylglycine as hosts in inclusion resolutions
Mueller, Simona,Ariaans, Gerry J. A.,Kaptein, Bernard,Broxterman, Quirinus B.,Formaggio, Fernando,Battan, Elisa,Crisma, Marco,Toniolo, Claudio,Bruggink, Alle
, p. 1919 - 1927 (2007/10/03)
Twelve homo-dipeptides derived from phenylglycine, Phg, and C α-methyl phenylglycine, (αMe)Phg, were synthesized and tested as resolving agents in resolutions through selective crystallization of inclusion compounds. The 3D-structure of a hydra
