86288-03-1

Upstream product

• 82551-63-1 4-nitrobenzyl 2-diazo-3-oxo-butanoate 
• 66363-43-7 (2S,5R,6S)-benzyl 6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 
• 59034-26-3 (2S,5R,6R)-benzyl 6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 

Downstream Products

• 100163-33-5 2-{(2R,3S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(Z)-2-hydroxy-1-(4-nitro-benzyloxycarbonyl)-propenylsulfanyl]-4-oxo-azetidin-1-yl}-3-methyl-but-2-enoic acid benzyl ester 
• 87095-97-4 {(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(2-methyl-[1,3]dioxolan-2-yl)-(4-nitro-benzyloxycarbonyl)-methylsulfanyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 100163-38-0 (Z)-2-{(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-1-[(4-nitro-benzyloxycarbonyl)-(triphenyl-λ⁵-phosphanylidene)-methyl]-4-oxo-azetidin-2-ylsulfanyl}-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester 
• 87095-99-6 [(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-nitro-benzyloxyoxalylsulfanyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 87095-96-3 Chloro-{(2R,3R)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[(2-methyl-[1,3]dioxolan-2-yl)-(4-nitro-benzyloxycarbonyl)-methylsulfanyl]-4-oxo-azetidin-1-yl}-acetic acid 4-nitro-benzyl ester 
• 87095-95-2 {(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(2-methyl-[1,3]dioxolan-2-yl)-(4-nitro-benzyloxycarbonyl)-methylsulfanyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 4-nitro-benzyl ester 
• 100044-47-1 2-{(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(2-methyl-[1,3]dioxolan-2-yl)-(4-nitro-benzyloxycarbonyl)-methylsulfanyl]-4-oxo-azetidin-1-yl}-3-methyl-but-2-enoic acid benzyl ester 
• 87096-01-3 (6R,7R)-7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2,4-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 87096-00-2 (5R,6R)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2,3-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 87095-94-1 [(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-2-ylsulfanyl]-(2-methyl-[1,3]dioxolan-2-yl)-acetic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

NOVEL TRANSFORMATION OF PENICILLIN INTO PENEM NUCLEUS : SYNTHESIS OF 2-CARBOXYLPENEM DERIVATIVE

A novel transformation of 6-aminopenicillanic acid (6-APA) into penem derivative is described.