862885-19-6

Upstream product

• 122684-33-7 methyl 1-tert-butoxycarbonyl-3-pyrrolidinecarboxylate 
• 72925-16-7 1-boc-pyrrolidine-3-carboxylic acid 
• 17012-21-4 1-benzylpyrrolidine-3-carboxylic acid methyl ester 
• 862885-17-4 N-(2-(trimethylsilyl)ethoxymethyl)-N-[2-iodo-4-methoxyphenyl]-1-{tert-butyloxycarbonyl}pyrrolidine-3-carboxamide 
• 862885-09-4 N-(2-iodo-4-methoxyphenyl)-1-{tert-butyloxycarbonyl}pyrrolidine-3-carboxamide 
• 862885-08-3 benzyl 1-{tert-butyloxycarbonyl}pyrrolidine-3-carboxylate 
• 862885-10-7 5-methoxy-2-oxo-1-(2-(trimethylsilanyl)ethoxymethyl)-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-1'-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Total synthesis of horsfiline: A palladium-catalyzed domino Heck-cyanation strategy

A total synthesis of horsfiline has been accomplished featuring a key intramolecular palladium-catalyzed domino Heck-cyanation sequence for the formation of the 3,3′-disubstituted oxindole. Georg Thieme Verlag Stuttgart.

Novel phosphorus radical-based routes to horsfiline

(Chemical Equation Presented) Radicals derived from the phosphorus reagents, ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO), are used in two related approaches to synthesis of the alkaloid horsfiline (1). In particular, DEPO proves