862885-75-4

Upstream product

• 724707-85-1 trifluoromethanesulfonic acid 7-methoxy-3,4-dihydronaphthalen-1-yl ester 
• 6836-19-7 7-Methoxy-1-tetralone 
• 862885-68-5 6-methoxy-4-(2,4,6-trimethoxyphenyl)-1,2-dihydronaphthalene 

Relevant academic research and scientific papers

General synthesis of 8-aryl-2-tetralones

Two alternative routes are described for the synthesis of 8-aryl-2-tetralones (1). Route A starts from α-tetralone 3 and involves 3 or 4 steps, with the selective Na-EtOH reduction of 1-aryl-7-methoxynaphthalenes 2 being the key step. The exclusive reduct

Ring selectivity in the Na/EtOH reduction of 1-aryl-7-methoxynaphthalenes

Na/EtOH reduction of 1-aryl-7-methoxynaphthalenes occurred preferentially at the A-ring when no substituents were present at the ortho-positions of the aryl group (up to 100% selectivity), to afford 1-aryl-7-methoxy-1,2,3,4- tetrahydronaphthalenes. Ortho-