862895-54-3Relevant academic research and scientific papers
A highly efficient palladacycle catalyst for hydrophenylation of C-, N-, and O-substituted bicyclic alkenes under aerobic condition
Yuan, Ke,Zhang, Ting Ke,Hou, Xue Long
, p. 6085 - 6088 (2005)
A new phosphine-free palladacycle catalyst 4 was prepared from benzyl oxazoline in high yield and fully characterized. With it as catalyst, hydrophenylation reactions of a wide range of bicyclic alkenes, not only norbomene and norborriadiene but also oxa-
A dramatic switch of enantioselectivity in asymmetric heck reaction by benzylic substituents of ligands
Wu, Wen-Qiong,Peng, Qian,Dong, Da-Xuan,Hou, Xue-Long,Wu, Yun-Dong
experimental part, p. 9717 - 9725 (2009/02/04)
A series of benzylic substituted P,N-ligands 1 and 2 have been synthesized. The Pd-complexes of these ligands show high catalytic activity and enantioselectivity in catalyzing the asymmetric Heck reaction. A dramatic switch in enantioselectivity is realized using ligands with and without substituents at the benzylic position of the ligand. Ligands 1 with H as the substituents offer products in (R)-configuration while ligands 2 with the methyl as substituents result in (S)-configuration products. In most cases high enantioselectivities are achieved. Density functional theory calculations on the reaction mechanism as well as X-ray analysis of 1a-PdCl2 and 2a-PdCl2 complexes provide a rational explanation for the above observations.
