862901-53-9

Upstream product

• 175140-75-7 (4,6-dichloro-2-methyl-pyrimidin-5-yl)-acetic acid ethyl ester 
• 7459-46-3 triethyl 1,1,2-ethanetricarboxylate 
• 474103-33-8 5-[1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl]-4,6-dichloro-2-methyl-pyrimidine 
• 474103-23-6 2-(4,6-dichloro-2-methyl-pyrimidin-5-yl)-pent-4-en-1-ol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 862901-72-2 methanesulfonic acid 3-{4-[tert-butoxycarbonyl-(4-cyano-2-methyl-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-4-(tert-butyl-diphenyl-silanyloxy)-butyl ester 
• 476645-16-6 4-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-chloro-2-methyl-6,7-dihydro-5H-pyrido[2,3-d]pyrimidin-8-yl]-3-methyl-benzonitrile 
• 476645-19-9 3-methyl-4-[7-methyl-1-(1-propyl-butyl)-2,2a,3,4-tetrahydro-1H-1,5,6,8-tetraaza-acenaphthylen-5-yl]-benzonitrile 
• 476645-18-8 4-[1-(1-ethyl-propyl)-7-methyl-2,2a,3,4-tetrahydro-1H-1,5,6,8-tetraaza-acenaphthylen-5-yl]-3-methyl-benzonitrile 
• 476645-17-7 4-(4-chloro-5-hydroxymethyl-2-methyl-6,7-dihydro-5H-pyrido[2,3-d]pyrimidin-8-yl)-3-methyl-benzonitrile 

Relevant academic research and scientific papers

Substituted tetraazaacenaphthylenes as potent CRF1 receptor antagonists for the treatment of depression and anxiety

Two isomers of the hexahydro-tetraazaacenaphthylene templates (1 and 2) are presented as novel, potent, and selective corticotropin releasing factor-1 (CRF1) receptor antagonists. In this paper, we report the affinity and SAR of a series of compounds, as well as pharmacokinetic characterization of a chosen set. The anxiolitic activity of a selected example (2ba) in the rat pup vocalization model is also presented.