862902-02-1Relevant academic research and scientific papers
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175
Piemontese, Luca,Fracchiolla, Giuseppe,Carrieri, Antonio,Parente, Mariagiovanna,Laghezza, Antonio,Carbonara, Giuseppe,Sblano, Sabina,Tauro, Marilena,Gilardi, Federica,Tortorella, Paolo,Lavecchia, Antonio,Crestani, Maurizio,Desvergne, Béatrice,Loiodice, Fulvio
, p. 583 - 594 (2015)
The effects resulting from the introduction of an oxime group in place of the distal aromatic ring of the diphenyl moiety of LT175, previously reported as a PPARα/γ dual agonist, have been investigated. This modification allowed the identification of new
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARα and PPARγ agonist activity
Pinelli, Alessandra,Godio, Cristina,Laghezza, Antonio,Mitro, Nico,Fracchiolla, Giuseppe,Tortorella, Vincenzo,Lavecchia, Antonio,Novellino, Ettore,Fruchart, Jean-Charles,Staels, Bart,Crestani, Maurizio,Loiodice, Fulvio
, p. 5509 - 5519 (2007/10/03)
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that govern lipid and glucose homeostasis playing a central role in cardiovascular diseases, obesity, and diabetes. Medications targeted to PPARs have been esta
