862910-52-9Relevant academic research and scientific papers
Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes
Han, Chong,Lee, Jonathan P.,Lobkovsky, Emil,Porco Jr., John A.
, p. 10039 - 10044 (2005)
A process for preparation of amides from unactivated esters and amines has been developed using a catalytic system comprised of group (IV) metal alkoxides in conjunction with additives including 1-hydroxy-7-azabenzotriazole (HOAt). In general, ester-amide exchange proceeds using a variety of structurally diverse esters and amines without azeotropic reflux to remove the alcohol byproduct. Initial mechanistic studies on the Zr(Ot-Bu)4-HOAt system revealed that the active catalyst is a novel, dimeric zirconium complex as determined by X-ray crystallography.
