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Research on nitro-derivatives of biological interest. XXVIII. Synthesis of hydrogenated analogs of 2-nitronaphthofuranes and activities against microorganisms
Einhorn,Demerseman,Rene,et al.
, p. 79 - 84 (2007/10/02)
The authors describe the various ways of transforming 5.6.7.8-tetrahydro 1- and 2-naphthols to 2-nitro 6.7.8.9-tetrahydronaphtho[2.1-b]furan, 2-nitro 5.6.7.8-tetrahydronaphtho[2.3-b]furan and 2-nitro 6.7.8.9-tetrahydronaphtho[1.2-b]furan as well as their derivatives methylated on the furan ring. Although the hydrogenated analogues of 2-nitronaphthofurans are less active than 2-nitronaphthofurans against bacteria, they tend to be more efficacious against protozoa. Their methylated derivatives are particularly efficient against these latter.
