862976-10-1Relevant articles and documents
Synthesis and cytotoxic evaluation of thiourea and N-bis-benzothiazole derivatives: A novel class of cytotoxic agents
Kumbhare, Ravindra M.,Dadmal, Tulshiram,Kosurkar, Umesh,Sridhar,Rao, J. Venkateswara
, p. 453 - 455 (2012)
Benzothiazolyl thiocarbamides has been achieved using a catalytic amount of 4-dimethylaminopyridine (DMAP) followed by its chemoselective oxidative cyclization with 1,3-di-n-butylimidazolium tribromide[bbim][Br3] to afford the N-bis-benzothiazole derivatives. All the synthesized compounds were evaluated for cytotoxic activity against two human monocytic cell lines (U 937, THP-1) and a mouse melanoma cell line (B16-F10). Based on their IC50 values, the majority of the benzothiazolyl thiocarbamides and N-bis-benzothiazoles had significant antiproliferative activity on U 937 and B16-F10 cells, the compounds 3b, 3e, 3f, 3k, 6c and 6h were found to be the most active. The present findings indicate clearly that the compound 3e exhibited more antiproliferative activity on U 937 cells than the standard molecule, etoposide. Nevertheless, these compounds have shown comparatively less cytotoxicity towards THP-1 cells.
1,3-Di-n-butylimidazolium tribromide-mediated chemoselective oxidative cyclization of benzothiazoyl carbaimides: A novel approach toward the synthesis of N-bis-benzothiazole derivatives
Kumbhare, Ravindra M.,Dadmal, Tulshiram,Kosurkar, Umesh,Vijay Kumar
, p. 342 - 348 (2012/06/15)
4-(N,N-Dimethylamino)pyridine is found to be an efficient catalyst for the synthesis of benzothiazoyl carbaimide derivatives using 2-aminobenzothiazoles and phenylisothiocyanates, which on treatment with ionic liquid [bbim][Br 3] at 70°C afforded exclusive formation of N-bis-benzothiazole derivatives in good yield. Copyright
