86298-22-8

Usage

Uses

New Benzotriazole ReagentsReactant for synthesis of azolecarboxylic acid derivatives

InChI:InChI=1/C8H7N3O2/c1-13-8(12)11-7-5-3-2-4-6(7)9-10-11/h2-5H,1H3

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 616-38-6 carbonic acid dimethyl ester 
• 101006-59-1 1-N-(1-ferrocenyl-1-methyl)ethylbenzotriazole 
• 7732-18-5 water 
• 79-22-1 methyl chloroformate 

Downstream Products

• 16584-00-2 2-methylbenzotriazole 
• 13351-73-0 1-methyl-1H-benzo[d][1,2,3]triazole 
• 5817-68-5 cyclohexyl-carbamic acid methyl ester 
• 537718-14-2 Carbonic acid (3S,7R,8S,9S,10R,11R,13S,14S)-7,11-bis-methoxycarbonyloxy-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester methyl ester 
• 30698-30-7 methyl 2-cyano-2-phenylacetate 

Relevant academic research and scientific papers

On the properties of the anions derived from α-deprotonation of α-(o-carboran-1-yl)- and α-ferrocenyl-1-alkylbenzotriazoles

The synthesis of 1-[(2-R-o-carboran-1-yl)methyl]benzotriazoles (R = Me, Ph) is described. α-Deprotonation of these compounds followed by reactions of the generated carbanions with MeI give the corresponding α-methylated products. Even at room temperature,

N-methylation of NH-containing heterocycles with dimethyl carbonate catalyzed by TMEDA

A practical method for N-methylation of NH-containing heterocycles using an environmentally safe and less toxic methylating reagent, dimethyl carbonate, has been developed. N,N,N',N'-tetramethylethylenediamine (TMEDA), an extremely active organocatalyst for the methylation of imides, indoles, benzimidazoles, and piperazines in conjunction with dimethyl carbonate, can lead to N-methylation products with high conversion. The reaction sequence consists of competing alkylation and acylation pathways and involves TMEDA as a nucleophilic catalyst. A possible reaction mechanism is discussed based on the reaction results.