86299-92-5Relevant academic research and scientific papers
Synthesis of 3,5-Disubstituted and 3,4,5-Trisubstituted λ3-Phosphorins from 1-tert-Butyl-1,6-dihydro-3(2H)-phosphorinones
Maerkl, Gottfried,Hock, Klaus,Merz, Loni
, p. 763 - 782 (2007/10/02)
5-Aryl-1-tert-butyl-1,6-dihydro-3(2H)-phosphorinones 13 - easily available by reduction of the phosphane oxides 1 with phenylsilane - react with 1 mol of RMgX (RLi) exclusively by formation of the enolates, however with 6 mol of RMgX (RLi), after reaction
Synthesis of 3,4- and 3,5-Disubstituted λ3- and λ5-Phosphorines from 5-Aryl-1-tert-butyl-1,6-dihydro-4-methyl-3(2H)-phosphorinone 1-Oxides
Maerkl, Gottfried,Hock, Klaus
, p. 1756 - 1776 (2007/10/02)
Starting from di(1-butynyl)-tert-butylphosphane (4) by reaction with aryl(bromomethyl)ketones the 4-(1-butynyl)-4-tert-butyl-2-ethyl-6-R-4H-1,4-oxaphosphorin-4-ium bromides 5 are formed.By alkaline degradation 5 give the 4-tert-butyl-2-ethyl-6-R-4H-1,4-oxaphosphorine 4-oxides 6.Treatment of 6 with refluxing ethanolic hydrochloric acid induces ether cleavagefollowed by aldol condensation to give the 5-aryl-1-tert-butyl-1,6-dihydro-4-methyl-3(2H)-phosphorinone 1-oxides (7).Reduction of 7 with silicochloroform leads to the 3-aryl-1-tert-butyl-1-chloro-4-methyl-λ5-phodphorins 8, which are thermolyzed at 250 - 270 deg C to give the 3-aryl-4-methyl-λ3-phosphorins 9 in good yields.During the reaction of 7 with silicochloroform 1,2-migration of the methyl group occurs to some extent - depending on the nature of the aryl group - and the 3-aryl-1-tert-butyl-1-chloro-5-methyl-λ5-phosphorins 12 are formed, which are thermolyzed to give the corresponding 3-aryl-5-methyl-λ3-phosphorins 10. - The 1H NMR, 13C NMR, 31P NMR, IR, UV, and mass spectra are discussed.
