863028-81-3Relevant academic research and scientific papers
Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors
Cui, Guonan,Jin, Jing,Chen, Hualong,Cao, Ran,Chen, Xiaoguang,Xu, Bailing
, p. 2186 - 2197 (2018/03/28)
Pin1 (Protein interacting with NIMA1) is a cis–trans isomerase and promotes the amide bond rotation of phosphoSer/Thr-Pro motifs in its substrates. Inhibition of Pin1 might be a novel strategy for developing anticancer agents. Herein, a series of pyrimidi
Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives
Hisamichi, Hiroyuki,Naito, Ryo,Toyoshima, Akira,Kawano, Noriyuki,Ichikawa, Atsushi,Orita, Akiko,Orita, Masaya,Hamada, Noritaka,Takeuchi, Makoto,Ohta, Mitsuaki,Tsukamoto, Shin-Ichi
, p. 4936 - 4951 (2007/10/03)
Spleen tyrosine kinase (Syk) is a non-receptor-type tyrosine kinase which mediates diverse responses in haematopoietic cells. Therefore, Syk is an attractive therapeutic target, and in a study of Syk inhibitors as potentially new therapeutic agents, we di
