86308-86-3Relevant academic research and scientific papers
Microwave-assisted synthesis of 2-phenoxybenzoic acids
Pellon, Rolando F.,Martin, Ana,Mesa, Miriam,Docampo, Maite L.,Gomez, Victoria
, p. 527 - 529 (2007/10/03)
Substituted 2-phenoxybenzoic acid derivatives were synthesised in high yield and in short reaction times using the Ullmann condensation of 2-chlorobenzoic acid with phenol derivatives under microwave irradiation in dry media.
The use of ultrasound in the synthesis of 2-carboxy substituted diphenylethers using water as solvent
Pellon Comdom, Rolando F.,Docampo Palacios, Maite L.
, p. 921 - 926 (2007/10/03)
An improved synthesis of 2-carboxy substituted diphenylethers using water as solvent can be achieved by ultrasound irradiation. A number of diphenylethers was prepared in good yields in a very short reaction time.
Substituted (2-Phenoxyphenyl)acetic Acids with Antiinflammatory Activity. 1
Atkinson, David C.,Godfrey, Keith E.,Meek, Bernard,Saville, John F.,Stillings, Michael R.
, p. 1353 - 1360 (2007/10/02)
The synthesis and antiinflammatory activity of a series of substituted (2-phenoxyphenyl)acetic acids are described.Initial screening in the adjuvant arthritis test showed that halogen substitution in the phenoxy ring enhanced activity considerably.Ulcerogenic potential, as measured by the minimum ulcerogenic dose (MUD), was low in almost all the acids tested. acetic acid possessed the most favorable combination of potency with low toxicity, including ulcerogenicity, and this compound is now in therapeutic use.
