86319-96-2

Upstream product

• 104-94-9 4-methoxy-aniline 
• 51550-17-5 5,6,7,8-tetrahydro-2-(methylthio)<1>benzothieno<2,3-d>pyrimidin-4(1H)-one 
• 4506-71-2 ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 13519-16-9 N-(4-methoxyphenyl)cyanamide 

Downstream Products

• 143770-19-8 5-<4-methoxyphenyl>amino-8,9,10,11-tetrahydro<1>benzothieno<3,2-e>tetrazolo<1,5-c>pyrimidine 
• 143770-33-6 4-amino-2-<4-methoxyphenyl>amino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine 
• 143770-14-3 4-chloro-2-(4-methoxyphenyl)amino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine 

Relevant academic research and scientific papers

Synthesis of 2-Amino- and 2-Guanidinothienopyrimidin-4(3H)-ones

Cyanamide and 1-arylcyanamides (2a-f) react with ethyl 2-aminothiophene-3-carboxylate (1a, R,R'= -(CH2)4-) to give 2-amino- and 2-arylaminothienopyrimidin-4(3H)-ones (3a-f, R''= H or Ar).A similar reaction of dicyandiamide (4a) and aryldicyandiamides (4b-f) with 1a gives 2-guanidino-thienopyrimidin-4(3H)-ones (5a-f, R''= H or Ar).However, ethyl 2-amino-4-methyl-5-(N-phenylcarboxamido)thiophene-3-carboxylate (1b, R = Me, R'= CONHPh) and ethyl 4-amino-2-imino-3-phenylthiazoline-5-carboxylate fail to give similar thieno- and thiazolo-pyrimidinones.Several new 2-(N-arylguanidino)quinazolin-4(3H)-ones (6a-e, R''= aryl) have been obtained from methyl anthranilate and aryldicyandiamides (4b-f).