863191-11-1

Basic information

• Product Name: 2,3-dimethoxymethoxyacetophenone
• Synonyms: 2,3-dimethoxymethoxyacetophenone
• CAS NO: 863191-11-1
• Molecular Weight: 240.256
• Mol File: 863191-11-1.mol

Chemical Properties

• CAS DataBase Reference: 2,3-dimethoxymethoxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dimethoxymethoxyacetophenone(863191-11-1)
• EPA Substance Registry System: 2,3-dimethoxymethoxyacetophenone(863191-11-1)

Safety Data

• Hazardous Substances Data: 863191-11-1(Hazardous Substances Data)

Upstream product

• 5653-62-3 2,3-dimethoxybenzonitrile 
• 703-98-0 1-(2-hydroxy-3-methoxyphenyl)ethanone 
• 13494-10-5 2',3'-dihydroxyacetophenone 
• 107-30-2 chloromethyl methyl ether 

Relevant articles and documents

Preparative monohydroxyflavanone syntheses and a protocol for gas chromatography-mass spectrometry analysis of monohydroxyflavanones

We describe a facile efficient, and preparative approach for monohydroxyflavanone syntheses. Using this protocol, a hydroxyl is regio-selectively introduced at one carbon of a flavanone A- or B-ring per synthesis. The seven possible isomers were each synthesized from the corresponding monomethoxymethoxylated 2′-hydroxychalcones in acidic solution. These monohydroxyflavanones were characterized using a gas chromatography-mass spectrometry (GC-MS) system that incorporated a DB-5 capillary column. Ours is the first report of a preparative synthetic method during which a single hydroxyl can be selectively added to a flavanone A- or B-ring at any position. We are also the first to develop a procedure that separates the seven isomers by GC and characterizes the mass spectra of the isomers. Both the synthetic method and the GC-MS conditions may become important tools during future flavanone metabolism and oxidation studies.