86321-28-0 Usage
Uses
Used in Metabolite Profiling:
Dihydro Ferulic Acid 4-O-β-D-Glucuronide is used as a biomarker in metabolite profiling for the identification of coffee consumption in humans. This application helps in understanding the metabolic effects of coffee intake and its potential impact on health.
Used in Nutritional Research:
In the field of nutritional research, Dihydro Ferulic Acid 4-O-β-D-Glucuronide is used to study the metabolic pathways and health effects associated with coffee consumption. This aids in developing a better understanding of the role of coffee and its components in human health and disease prevention.
Used in Clinical Diagnostics:
Dihydro Ferulic Acid 4-O-β-D-Glucuronide can be employed as a diagnostic tool in clinical settings to determine an individual's coffee consumption habits. This information can be valuable in assessing the potential risks and benefits of coffee intake for specific health conditions and providing personalized recommendations.
Check Digit Verification of cas no
The CAS Registry Mumber 86321-28-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,3,2 and 1 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 86321-28:
(7*8)+(6*6)+(5*3)+(4*2)+(3*1)+(2*2)+(1*8)=130
130 % 10 = 0
So 86321-28-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H20O10/c1-24-9-6-7(3-5-10(17)18)2-4-8(9)25-16-13(21)11(19)12(20)14(26-16)15(22)23/h2,4,6,11-14,16,19-21H,3,5H2,1H3,(H,17,18)(H,22,23)/t11-,12-,13+,14-,16+/m0/s1
86321-28-0Relevant academic research and scientific papers
First synthesis, characterization, and evidence for the presence of hydroxycinnamic acid sulfate and glucuronide conjugates in human biological fluids as a result of coffee consumption
Fumeaux, Rene,Menozzi-Smarrito, Candice,Stalmach, Angelique,Munari, Caroline,Kraehenbuehl, Karin,Steiling, Heike,Crozier, Alan,Williamson, Gary,Barron, Denis
supporting information; experimental part, p. 5199 - 5211 (2010/12/25)
A systematic investigation of the human metabolism of hydroxycinnamic acid conjugates was carried out. A set of 24 potential human metabolites of coffee polyphenols has been chemically prepared, and used as analytical standards for unequivocal identifications. These included glucuronide conjugates and sulfate esters of caffeic, ferulic, isoferulic, m-coumaric and p-coumaric acids as well as their dihydro derivatives. A particular focus has been made on caffeic and 3,4-dihydroxyphenylpropionic acid derivatives, especially the sulfate conjugates, for which regioselective preparation was particularly challenging, and have so far never been identified as human metabolites. Ten out of the 24 synthesized conjugates have been identified in human plasma and/or urine after coffee consumption. A number of these conjugates were synthesized, characterized and detected as hydroxycinnamic acid metabolites for the first time. This was the case of dihydroisoferulic acid 3′-O-glucuronide, caffeic acid 3′-sulfate, as well as the sulfate and glucuronide derivatives of 3,4-dihydroxyphenylpropionic acid.
